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KMID : 0378019910340100079
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New Medical Journal
1991 Volume.34 No. 10 p.79 ~ p.84
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The Antiepileptic Effect of Zonisamide(P-132)
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Abstract
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Zonisamide. new antiepileptic drug, was administered to 25 epileptic patients(13 refractory and 12 new cases)for 6 months. The drug efficacy, serum-level of zonisamide and side effects were investigated.
Clinically improved or; disappeared of seizures were 16 in 25 patients(8 in 13 of refractory´ cases and 8 in 12 of new cases). In type of seizures, rate of improved was 66.7% in generalized tonic clonic sezure, 88.8% in generalized tonic clonic sezure with partial onset, 25.0% in complex partial seizure, 100.0% in simple partial seizure. Neverthless mixed type with complex partial seizure and generlized tonic clonic seizure was not responded to the zonisamide.
The average effective serum concentration of zonisamide was 21.8 ug/ml and mean dose given was 4.8mg/kg/day(23.4 ug/ml in refractory case and 20.3ug/ini in new case).
Side effects were observed in 13(52%) of 25. cases. These were most commonly toss of weight(32%) and anorexia (28%). These side effects were frequently found within three months after initiation of administered and disappeared thereafter.
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